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NTRK3 antibody (Neurotrophic tyrosine Kinase, Receptor, Type 3) (pTyr820)

Details for Product anti-NTRK3 Antibody No. ABIN350739, Supplier: Log in to see
Antigen
  • TRKC
  • gp145(trkC)
  • AW125844
  • Ntrk3_tv3
  • TrkC
  • trkC
  • neurotrophic tyrosine kinase, receptor, type 3
  • NTRK3
  • LOC100227403
  • Ntrk3
Alternatives
anti-Human NTRK3 antibody for Immunohistochemistry
Epitope
pTyr820
44
15
15
12
10
8
7
7
6
5
5
4
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus), Mouse (Murine), Human
150
64
40
4
2
2
1
1
1
1
Host
Rabbit
112
53
12
6
3
Clonality
Polyclonal
Conjugate
This NTRK3 antibody is un-conjugated
9
4
4
4
4
4
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
140
86
76
22
14
12
5
1
1
1
1
Options
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Immunogen A synthetic peptide to phospho Y820 of human TrkC conjugated to blue carrier protein was used as the antigen. The antigen is homologous in rat and mouse. The peptide is homologous in rat and mouse.
Isotype IgG
Specificity Specific for TrkC.
Alternative Name TrkC (NTRK3 Antibody Abstract)
Target Type Tag
Background Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
Subcellular location: Membrane, Single-pass type I membrane protein.
Tissue specificity: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. Also known as: Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3.
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications. This antibody may also recognise the unphosphorylated form.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Ballif, Carey, Sunyaev, Gygi: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008 (PubMed).

Qian, Riccio, Zhang, Ginty: "Identification and characterization of novel substrates of Trk receptors in developing neurons." in: Neuron, Vol. 21, Issue 5, pp. 1017-29, 1999 (PubMed).

Ultsch, Wiesmann, Simmons, Henrich, Yang, Reilly, Bass, de Vos: "Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC." in: Journal of molecular biology, Vol. 290, Issue 1, pp. 149-59, 1999 (PubMed).

McGregor, Baylin, Griffin, Hawkins, Nelkin: "Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant." in: Genomics, Vol. 22, Issue 2, pp. 267-72, 1995 (PubMed).

Shelton, Sutherland, Gripp, Camerato, Armanini, Phillips, Carroll, Spencer, Levinson: "Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 1 Pt 2, pp. 477-91, 1995 (PubMed).

Merlio, Ernfors, Jaber, Persson: "Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system." in: Neuroscience, Vol. 51, Issue 3, pp. 513-32, 1993 (PubMed).

Tsoulfas, Soppet, Escandon, Tessarollo, Mendoza-Ramirez, Rosenthal, Nikolics, Parada: "The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells." in: Neuron, Vol. 10, Issue 5, pp. 975-90, 1993 (PubMed).

Valenzuela, Maisonpierre, Glass, Rojas, Nuunez, Kong, Gies, Stitt, Ip, Yancopoulos: "Alternative forms of rat TrkC with different functional capabilities." in: Neuron, Vol. 10, Issue 5, pp. 963-74, 1993 (PubMed).