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PIM1 antibody (Pim-1 Oncogene) (Internal Region)

Details for Product anti-PIM1 Antibody No. ABIN350744, Supplier: Log in to see
Antigen
  • cb1068
  • fj47b05
  • hLON
  • LON
  • LonHS
  • LONP
  • PIM
  • pim
  • pim-1
  • Pim-1
  • PIM1
  • pim2
  • pim3
  • PRSS15
  • wu:fj47b05
Epitope
Internal Region
40
24
22
18
17
15
13
12
10
9
8
6
5
5
5
5
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
177
46
46
1
1
1
Host
Rabbit
138
52
5
Clonality
Polyclonal
Conjugate
This PIM1 antibody is un-conjugated
12
8
6
5
4
4
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
132
105
59
59
44
20
11
6
5
3
1
1
Supplier
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Immunogen A synthetic peptide from the internal region of human PIM1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse.
Specificity Specific for PIM1.
Purification Whole serum
Alternative Name PIM1 (PIM1 Antibody Abstract)
Background Function: Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1.Nucleus
Tissue specificity: Appears to be expressed in a wide range of tissues. DISEASE: Defects in RP9 are the cause of retinitis pigmentosa type 9 (RP9). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP9 inheritance is autosomal dominant. Also known as: Retinitis pigmentosa 9 protein, RP9, Pim-1-associated protein, PAP-1.
Research Area Cancer, Hematopoietic Progenitors
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Kuroda, Maita, Tabata, Taira, Kitaura, Ariga, Iguchi-Ariga: "A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase." in: Gene, Vol. 340, Issue 1, pp. 83-98, 2004

Keen, Hims, McKie, Moore, Doran, Mackey, Mansfield, Mueller, Bhattacharya, Bird, Markham, Inglehearn: "Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa." in: European journal of human genetics : EJHG, Vol. 10, Issue 4, pp. 245-9, 2002