Pim-1 Oncogene (PIM1) (internal) antibody

Antigen: Pim-1 Oncogene (PIM1)

Synonyms: PIM, Pim-1, pim2, cb1068, fj47b05, wu:fj47b05, pim1-a, PIM1, pim3, MGC89574, pim-1, PAP-1

Epitope: internal

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350744

Additional Information

Alternative name: PIM1 (Retinitis pigmentosa 9 protein) (internal region)

Swiss-Prot: Q8TA86

Immunogen: A synthetic peptide from the internal region of human PIM1 (Retinitis pigmentosa 9 protein) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1.Nucleus TISSUE SPECIFICITY: Appears to be expressed in a wide range of tissues. DISEASE: Defects in RP9 are the cause of retinitis pigmentosa type 9 (RP9). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP9 inheritance is autosomal dominant. Also known as: Retinitis pigmentosa 9 protein, RP9, Pim-1-associated protein, PAP-1.

Specificity: Appears to be specific for PIM1.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Keen, Hims, McKie et al.: "Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa." in: European journal of human genetics : EJHG, Vol. 10, Issue 4, pp. 245-9, 2002 (PubMed).

Kuroda, Maita, Tabata et al.: "A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase." in: Gene, Vol. 340, Issue 1, pp. 83-98, 2004 (PubMed).