You are viewing an incomplete version of our website. Please click to reload the website as full version.

PKD2 antibody (Polycystic Kidney Disease 2 (Autosomal Dominant)) (4th Cytoplasmic Loop)

Details for Product anti-PKD2 Antibody No. ABIN350745, Supplier: Log in to see
Antigen
  • C030034P18Rik
  • PC2
  • TRPP2
  • APKD2
  • PKD4
  • Pc-2
  • RGD1559992
  • AI325941
  • PKD2
  • polycystic kidney disease 2
  • polycystic kidney disease 2 (autosomal dominant)
  • protein kinase D2
  • Protein PKD-2
  • Pkd2
  • PKD2
  • Prkd2
  • pkd-2
Alternatives
anti-Human PKD2 antibody for Immunohistochemistry (Frozen Sections)
Epitope
4th Cytoplasmic Loop
17
15
5
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
73
62
37
4
2
2
2
2
2
1
1
1
Host
Rabbit
75
8
4
Clonality
Polyclonal
Conjugate
This PKD2 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
63
47
13
13
12
11
7
2
2
1
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Immunogen A synthetic peptide from the 4th cytoplasmic loop of human PKD2 conjugated to blue carrier protein was used as the antigen.
Specificity Specific for PKD2.
Purification Whole serum
Alternative Name PKD2 (PKD2 Antibody Abstract)
Background Function: Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
Subunit: Interacts with PKD1. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes. DISEASE: Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2). ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy. Also known as: PKD2, Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystwin, R48321.
Pathways cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Molina, Horn, Tang, Mathivanan, Pandey: "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 7, pp. 2199-204, 2007 (PubMed).

Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Stayner, Zhou: "Polycystin channels and kidney disease." in: Trends in pharmacological sciences, Vol. 22, Issue 11, pp. 543-6, 2001 (PubMed).

Lehtonen, Ora, Olkkonen, Geng, Zerial, Somlo, Lehtonen: "In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2." in: The Journal of biological chemistry, Vol. 275, Issue 42, pp. 32888-93, 2000 (PubMed).

Watnick, He, Wang, Liang, Parfrey, Hefferton, St George-Hyslop, Germino, Pei: "Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations." in: Nature genetics, Vol. 25, Issue 2, pp. 143-4, 2000 (PubMed).

Torra, Viribay, Tellería, Badenas, Watson, Harris, Darnell, San Millán: "Seven novel mutations of the PKD2 gene in families with autosomal dominant polycystic kidney disease." in: Kidney international, Vol. 56, Issue 1, pp. 28-33, 1999 (PubMed).

Hayashi, Mochizuki, Reynolds, Wu, Cai, Somlo: "Characterization of the exon structure of the polycystic kidney disease 2 gene (PKD2)." in: Genomics, Vol. 44, Issue 1, pp. 131-6, 1997 (PubMed).

Schneider, Rodriguez, Nomura, Zhou, Morton, Reeders, Weremowicz: "A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2." in: Genomics, Vol. 38, Issue 1, pp. 1-4, 1997 (PubMed).

Veldhuisen, Saris, de Haij, Hayashi, Reynolds, Mochizuki, Elles, Fossdal, Bogdanova, van Dijk, Coto, Ravine, Nuorby, Verellen-Dumoulin, Breuning, Somlo, Peters: "A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2)." in: American journal of human genetics, Vol. 61, Issue 3, pp. 547-55, 1997 (PubMed).

Mochizuki, Wu, Hayashi, Xenophontos, Veldhuisen, Saris, Reynolds, Cai, Gabow, Pierides, Kimberling, Breuning, Deltas, Peters, Somlo: "PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein." in: Science (New York, N.Y.), Vol. 272, Issue 5266, pp. 1339-42, 1996 (PubMed).