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Details for Product No. ABIN350745

Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (4th Cytoplasmic Loop) antibody

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Antigen
Synonyms APKD2, PC2, PKD4, Pc-2, TRPP2, RGD1559992
Epitope
»Alternatives 4th Cytoplasmic Loop
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 10 references available
Catalog no. ABIN350745
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 4th cytoplasmic loop of human Polycystic kidney disease 2 protein (PKD2, Polycystin-2, Polycystwin) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for PKD2.
Purity whole serum
Alternative Name polycystic kidney disease 2 protein (PKD2, Polycystin-2)
Background Function: Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
Subunit: Interacts with PKD1. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes. DISEASE: Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2). ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy. Also known as: PKD2, Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystwin, R48321.
UniProt Q13563
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Mochizuki, Wu, Hayashi et al.: "PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein." in: Science (New York, N.Y.), Vol. 272, Issue 5266, pp. 1339-42, 1996 (PubMed).

Schneider, Rodriguez, Nomura et al.: "A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2." in: Genomics, Vol. 38, Issue 1, pp. 1-4, 1997 (PubMed).

Hayashi, Mochizuki, Reynolds et al.: "Characterization of the exon structure of the polycystic kidney disease 2 gene (PKD2)." in: Genomics, Vol. 44, Issue 1, pp. 131-6, 1997 (PubMed).

Veldhuisen, Saris, de Haij et al.: "A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2)." in: American journal of human genetics, Vol. 61, Issue 3, pp. 547-55, 1997 (PubMed).

Torra, Viribay, Tellería et al.: "Seven novel mutations of the PKD2 gene in families with autosomal dominant polycystic kidney disease." in: Kidney international, Vol. 56, Issue 1, pp. 28-33, 1999 (PubMed).

Watnick, He, Wang et al.: "Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations." in: Nature genetics, Vol. 25, Issue 2, pp. 143-4, 2000 (PubMed).

Lehtonen, Ora, Olkkonen et al.: "In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2." in: The Journal of biological chemistry, Vol. 275, Issue 42, pp. 32888-93, 2000 (PubMed).

Stayner, Zhou: "Polycystin channels and kidney disease." in: Trends in pharmacological sciences, Vol. 22, Issue 11, pp. 543-6, 2001 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Molina, Horn, Tang et al.: "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 7, pp. 2199-204, 2007 (PubMed).

Alternatives for antigen "Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2)", type "Antibodies"
Hosts (54), (3), (3)
Reactivities (56), (45), (37), (13), (12), (12), (1), (1)
Applications (44), (38), (10), (9), (7), (7), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (19), (7), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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