Polycystic Kidney Disease 2-Like 1 (PKD2L1) (1st Cytoplasmic Loop) antibody

Details for Product No. ABIN350746
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Antigen
Synonyms PKD2L1, si:packtrz.2, si:xx-packtrz.2, B830002B15, BC046386, PCL, PKD2L, Pkdl, TRPP3, PKDL
Epitope
1st Cytoplasmic Loop
(10), (8), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(18), (5), (3)
Host
Rabbit
(20), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(21), (12), (2), (1), (1), (1)
Pubmed 6 references available
Quantity 100 μL
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Catalog No. ABIN350746
454.67 $
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Immunogen A synthetic peptide from the 1t cytoplasmic loop of human PK2L1 conjugated to blue carrier protein was used as the antigen.
Specificity Specific for PKD2L1.
Purification Whole serum
Alternative Name PKD2L1
Background This gene encodes a member of the polycystin protein family. The encoded protein contains multipletransmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined
Function: May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. According to Ref.1 expressed at high levels in fetal tissues, including kidney and liver, and down-regulated in adult tissues. It has been found to be expressed in fetal brain, but not expressed in fetal lung, liver or kidney. Isoform 4 appears to be expressed only in transformed lymphoblasts. Also known as: PK2L1, PKD2L1, PKD2L, PKDL, Polycystin-L.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Nomura, Turco, Pei et al.: "Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects." in: The Journal of biological chemistry, Vol. 273, Issue 40, pp. 25967-73, 1998 (PubMed).

Wu, Hayashi, Park et al.: "Identification of PKD2L, a human PKD2-related gene: tissue-specific expression and mapping to chromosome 10q25." in: Genomics, Vol. 54, Issue 3, pp. 564-8, 1999 (PubMed).

Chen, Vassilev, Basora et al.: "Polycystin-L is a calcium-regulated cation channel permeable to calcium ions." in: Nature, Vol. 401, Issue 6751, pp. 383-6, 1999 (PubMed).

Veldhuisen, Spruit, Dauwerse et al.: "Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2)." in: European journal of human genetics : EJHG, Vol. 7, Issue 8, pp. 860-72, 2000 (PubMed).

Guo, Chen, Basora et al.: "The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 11, Issue 1, pp. 46-50, 2000 (PubMed).

Stayner, Zhou: "Polycystin channels and kidney disease." in: Trends in pharmacological sciences, Vol. 22, Issue 11, pp. 543-6, 2001 (PubMed).

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