polycystic kidney disease 2-like 2 protein (PKD2L2, PK2L2, Polycystin-L2) (4th Cytoplasmic Loop) antibody

Antigen: polycystic kidney disease 2-like 2 protein (PKD2L2, PK2L2, Polycystin-L2)

Binding Site: 4th Cytoplasmic Loop

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350749

Additional Information

UniProt: Q9NZM6

Immunogen: A synthetic peptide from the 4th cytoplasmic loop of human Polycystic kidney disease 2-like 2 protein (PKD2L2, PK2L2, Polycystin-L2) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: May function as a subunit of a cation channel and play a role in fertilization. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Also known as: PKD2L2, PK2L2, Polycystin-L2.

Specificity: Appears to be specific for PKD2L2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Veldhuisen, Spruit, Dauwerse et al.: "Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2)." in: European journal of human genetics : EJHG, Vol. 7, Issue 8, pp. 860-72, 2000 (PubMed).

Guo, Schreiber, Weremowicz et al.: "Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization." in: Genomics, Vol. 64, Issue 3, pp. 241-51, 2000 (PubMed).

Stayner, Zhou: "Polycystin channels and kidney disease." in: Trends in pharmacological sciences, Vol. 22, Issue 11, pp. 543-6, 2001 (PubMed).