Polycystic Kidney Disease (Polycystin) and REJ Homolog (Sperm Receptor For Egg Jelly Homolog, Sea Urchin) (PKDREJ) (2d cytoplasmic loop) antibody

Antigen: Polycystic Kidney Disease (Polycystin) and REJ Homolog (Sperm Receptor For Egg Jelly Homolog, Sea Urchin) (PKDREJ)

Epitope: 2d cytoplasmic loop

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350750

Additional Information

Alternative name: polycystic kidney disease and receptor for egg jelly-related protein (PKDREJ) (2d cytoplasmic loop)

Swiss-Prot: Q9NTG1

Immunogen: A synthetic peptide from the 2d cytoplasmic loop of human Polycystic kidney disease and receptor for egg jelly-related protein (PKDREJ) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined. FUNCTION: May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm. SUBUNIT: May form homomultimers or heteromultimers in combination with an as yet unidentified subunits. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Exclusively expressed in testis. Also known as: PKDREJ.

Specificity: Appears to be specific for PKDREJ.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Hughes, Ward, Aspinwall et al.: "Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein." in: Human molecular genetics, Vol. 8, Issue 3, pp. 543-9, 1999 (PubMed).

Stayner, Zhou: "Polycystin channels and kidney disease." in: Trends in pharmacological sciences, Vol. 22, Issue 11, pp. 543-6, 2001 (PubMed).

Sjoeblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).