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Details for Product No. ABIN350750

Polycystic Kidney Disease (Polycystin) and REJ Homolog (Sperm Receptor For Egg Jelly Homolog, Sea Urchin) (PKDREJ) (2nd Cytoplasmic Loop) antibody

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»Alternatives 2nd Cytoplasmic Loop
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN350750
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the 2d cytoplasmic loop of human Polycystic kidney disease and receptor for egg jelly-related protein (PKDREJ) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for PKDREJ.
Purity whole serum
Alternative Name polycystic kidney disease and receptor for egg jelly-related protein (PKDREJ)
Background This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined.
Function: May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm.
Subunit: May form homomultimers or heteromultimers in combination with an as yet unidentified subunits.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Exclusively expressed in testis. Also known as: PKDREJ.
UniProt Q9NTG1
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Hughes, Ward, Aspinwall et al.: "Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein." in: Human molecular genetics, Vol. 8, Issue 3, pp. 543-9, 1999 (PubMed).

Stayner, Zhou: "Polycystin channels and kidney disease." in: Trends in pharmacological sciences, Vol. 22, Issue 11, pp. 543-6, 2001 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Alternatives for antigen "Polycystic Kidney Disease (Polycystin) and REJ Homolog (Sperm Receptor For Egg Jelly Homolog, Sea Urchin) (PKDREJ)", type "Antibodies"
Hosts (4)
Reactivities (3)
Applications (4), (1), (1), (1)
Epitopes (1), (1)