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Polycystic Kidney Disease (Polycystin) and REJ Homolog (Sperm Receptor For Egg Jelly Homolog, Sea Urchin) (PKDREJ) (2nd Cytoplasmic Loop) antibody

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2nd Cytoplasmic Loop
(2), (2)
Immunohistochemistry (IHC), Western Blotting (WB)
(5), (1)
Pubmed 3 references available
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Quantity 100 μL
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Immunogen A synthetic peptide from the 2d cytoplasmic loop of human Polycystic kidney disease and receptor for egg jelly-related protein (PKDREJ) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for PKDREJ.
Purification Whole serum
Alternative Name PKDREJ
Background This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined.
Function: May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm.
Subunit: May form homomultimers or heteromultimers in combination with an as yet unidentified subunits.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Exclusively expressed in testis. Also known as: PKDREJ.
Research Area Reproduction
Application Notes A dilution of 1 : 300 to 1 : 3000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Stayner, Zhou: "Polycystin channels and kidney disease." in: Trends in pharmacological sciences, Vol. 22, Issue 11, pp. 543-6, 2001 (PubMed).

Hughes, Ward, Aspinwall et al.: "Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein." in: Human molecular genetics, Vol. 8, Issue 3, pp. 543-9, 1999 (PubMed).

Catalog No. ABIN350750
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