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Polycystic Kidney Disease (Polycystin) and REJ Homolog (Sperm Receptor For Egg Jelly Homolog, Sea Urchin) (PKDREJ) (Cytoplasmic Loop) antibody

Details for Product No. ABIN350750
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Antigen
Epitope
Cytoplasmic Loop
(1), (1)
Reactivity
Human
(2)
Host
Rabbit
(3)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(3)
Pubmed 3 references available
Quantity 100 µL
Options
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Availability Will be delivered in 7 to 8 Business Days
Catalog No. ABIN350750
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the 2d cytoplasmic loop of human Polycystic kidney disease and receptor for egg jelly-related protein (PKDREJ) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for CATSPER2.
Purification whole serum
Alternative Name PKDREJ
Background This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined.
Function: May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm.
Subunit: May form homomultimers or heteromultimers in combination with an as yet unidentified subunits.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Exclusively expressed in testis. Also known as: PKDREJ.
UniProt Q96P56
Application Notes A dilution of 1 : 300 to 1 : 3000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Hughes, Ward, Aspinwall et al.: "Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein." in: Human molecular genetics, Vol. 8, Issue 3, pp. 543-9, 1999 (PubMed).

Stayner, Zhou: "Polycystin channels and kidney disease." in: Trends in pharmacological sciences, Vol. 22, Issue 11, pp. 543-6, 2001 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350750
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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