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Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (C-Term) antibody

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Synonyms PBP, Pc-1, TRPP1, PC1, mFLJ00285, PKD, PKD1, Pkcm, Prkcm
(13), (7), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(37), (27), (13), (2), (2)
(29), (9)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(14), (14), (14), (11), (7), (2)
Pubmed 8 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the c-terminal region of human polycystic kidney disease protein 1 (PKD1) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for PKD1.
Purification Whole serum
Alternative Name PKD1 (PKD1 Antibody Abstract)
Background This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multipletransmembrane domains and a cytoplasmic C-tail. It may function as an integral membrane protein involved in cell-cell/matrix interactions, and may modulate intracellular calcium homoeostasis and other signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene have been associated with autosomal dominant polycystic kidney disease. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.
Function: May be an ion-channel regulator. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Involved in adhesive protein-protein and protein-carbohydrate interactions.
Subunit: Interacts with PKD2.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Polycystin-1, PKD1, Autosomal dominant polycystic kidney disease protein 1, PBP.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Stayner, Zhou: "Polycystin channels and kidney disease." in: Trends in pharmacological sciences, Vol. 22, Issue 11, pp. 543-6, 2001 (PubMed).

Tsuchiya, Komeda, Takahashi et al.: "Mutational analysis within the 3' region of the PKD1 gene in Japanese families." in: Mutation research, Vol. 458, Issue 3-4, pp. 77-84, 2001 (PubMed).

Bouba, Koptides, Mean et al.: "Novel PKD1 deletions and missense variants in a cohort of Hellenic polycystic kidney disease families." in: European journal of human genetics : EJHG, Vol. 9, Issue 9, pp. 677-84, 2001 (PubMed).

Phakdeekitcharoen, Watnick, Ahn et al.: "Thirteen novel mutations of the replicated region of PKD1 in an Asian population." in: Kidney international, Vol. 58, Issue 4, pp. 1400-12, 2000 (PubMed).

Perrichot, Mercier, Quere et al.: "Novel mutations in the duplicated region of PKD1 gene." in: European journal of human genetics : EJHG, Vol. 8, Issue 5, pp. 353-9, 2000 (PubMed).

Peral, Gamble, Strong et al.: "Identification of mutations in the duplicated region of the polycystic kidney disease 1 gene (PKD1) by a novel approach." in: American journal of human genetics, Vol. 60, Issue 6, pp. 1399-410, 1997 (PubMed).

Hughes, Ward, Peral et al.: "The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains." in: Nature genetics, Vol. 10, Issue 2, pp. 151-60, 1995 (PubMed).

Catalog No. ABIN350751
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