Polycystic Kidney Disease 1-Like 2 (PKD1L2) (7th extracellular loop) antibody

Antigen: Polycystic Kidney Disease 1-Like 2 (PKD1L2)

Synonyms: 1700126L06Rik, PC1L2, FLJ45333, DKFZp686J19100

Epitope: 7th extracellular loop

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350757

Additional Information

Alternative name: polycystic kidney disease protein 1-like 2 (PK1L2, Polycystin-1L2, PKD1L2) (7th extracellular loop)

Swiss-Prot: Q7Z442

Immunogen: A synthetic peptide from the 7th extracellular loop of human Polycystic kidney disease protein 1-like 2 (PK1L2, Polycystin-1L2) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: This gene encodes a member of the polycystin protein family. The encoded protein contains 11transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. Two transcript variants encoding different isoforms have been found for this gene. FUNCTION: May function as an ion-channel regulator. May function as a G-protein-coupled receptor. SUBUNIT: May interact via its C-terminus with GNAS and GNAI1. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Also known as: Polycystin-1L2, PC1-like 2 protein, PKD1L2, PC1L2.

Specificity: Appears to be specific for PK1L2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Nagase, Kikuno, Ohara: "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 8, Issue 4, pp. 179-87, 2001 (PubMed).

Li, Tian, Sung et al.: "Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes." in: Genomics, Vol. 81, Issue 6, pp. 596-608, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Yuasa, Takakura, Denker et al.: "Polycystin-1L2 is a novel G-protein-binding protein." in: Genomics, Vol. 84, Issue 1, pp. 126-38, 2004 (PubMed).