Polycystic Kidney Disease 1 Like 3 (PKD1L3) (1t extracellular loop) antibody

Antigen: Polycystic Kidney Disease 1 Like 3 (PKD1L3)

Epitope: 1t extracellular loop

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350758

Additional Information

Alternative name: polycystic kidney disease protein 1-like 3 (PKD1L3, PK1L3, Polycystin-1L3) (1t extracellular loop)

Swiss-Prot: Q2EG98

Immunogen: A synthetic peptide from the 4th extracellular domain of mouse Polycystic kidney disease protein 1-like 3 (PKD1L3, PK1L3, Polycystin-1L3) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: May function as an ion-channel regulator. May function with PKD2L1 as heteromeric taste channels. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in placenta, weakly in heart and lung. Also known as: PKD1L3, PK1L3, Polycystin-1L3, PC1-like 3 protein.

Specificity: Appears to be specific for PKD1L3.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Li, Tian, Sung et al.: "Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes." in: Genomics, Vol. 81, Issue 6, pp. 596-608, 2003 (PubMed).

LopezJimenez, Cavenagh, Sainz et al.: "Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells." in: Journal of neurochemistry, Vol. 98, Issue 1, pp. 68-77, 2006 (PubMed).