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Details for Product No. ABIN350759

Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (1st Cytoplasmic Domain) antibody

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Antigen
Synonyms HCN2, BCNG2, HAC-1, BCNG-2, HAC1, trls, wu:fj61d07, si:dkey-28h18.1
Epitope
»Alternatives 1st Cytoplasmic Domain
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350759
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the 1t cytoplasmic domain of human potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for HCN2.
Purity whole serum
Alternative Name potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 2 (HCN2)
Background HCN2:
Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH, acidic pH shifts the activation to more negative voltages.
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Highly expressed in neonatal and adult ventricle and in brain. Highly expressed in the pyramidal layer in hippocampus, in anterior dorsal nucleus in thalamus, in the mammillary nucleus in hypothalamus, in red nucleus, in trigeminal mesencephalic, spinal and principal nuclei, in cochlear and trapezoid nuclei and in the dorsal tegemental nucleus. Also known as: HCN2 (Brain cyclic nucleotide-gated channel 2, BCNG-2, BCNG2, HAC-1).
UniProt Q9UL51
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Santoro, Liu, Yao et al.: "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain." in: Cell, Vol. 93, Issue 5, pp. 717-29, 1998 (PubMed).

Ludwig, Zong, Stieber et al.: "Two pacemaker channels from human heart with profoundly different activation kinetics." in: The EMBO journal, Vol. 18, Issue 9, pp. 2323-9, 1999 (PubMed).

Vaccari, Moroni, Rocchi et al.: "The human gene coding for HCN2, a pacemaker channel of the heart." in: Biochimica et biophysica acta, Vol. 1446, Issue 3, pp. 419-25, 1999 (PubMed).

Grimwood, Gordon, Olsen et al.: "The DNA sequence and biology of human chromosome 19." in: Nature, Vol. 428, Issue 6982, pp. 529-35, 2004 (PubMed).

Alternatives for antigen "Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2)", type "Antibodies"
Hosts (40), (5), (1)
Reactivities (39), (33), (30), (17), (17)
Applications (32), (21), (15), (12), (10), (3), (3), (3), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (4), (3), (1), (1), (1)
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