Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (Cytoplasmic Domain) antibody

Details for Product No. ABIN350759
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Antigen
Synonyms HCN2, BCNG2, HAC-1, BCNG-2, HAC1, trls, wu:fj61d07, si:dkey-28h18.1
Epitope
Cytoplasmic Domain
(20), (9), (3), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(49), (40), (29), (17), (17), (2)
Host
Rabbit
(40), (22), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(49), (28), (22), (20), (18), (14), (3), (3), (2), (2), (1)
Pubmed 4 references available
Catalog no. ABIN350759
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the 1t cytoplasmic domain of human potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for TRPV4.
Purification whole serum
Alternative Name potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 2 (HCN2)
Background HCN2:
Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH, acidic pH shifts the activation to more negative voltages.
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Highly expressed in neonatal and adult ventricle and in brain. Highly expressed in the pyramidal layer in hippocampus, in anterior dorsal nucleus in thalamus, in the mammillary nucleus in hypothalamus, in red nucleus, in trigeminal mesencephalic, spinal and principal nuclei, in cochlear and trapezoid nuclei and in the dorsal tegemental nucleus. Also known as: HCN2 (Brain cyclic nucleotide-gated channel 2, BCNG-2, BCNG2, HAC-1).
UniProt Q9ERZ8
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Santoro, Liu, Yao et al.: "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain." in: Cell, Vol. 93, Issue 5, pp. 717-29, 1998 (PubMed).

Ludwig, Zong, Stieber et al.: "Two pacemaker channels from human heart with profoundly different activation kinetics." in: The EMBO journal, Vol. 18, Issue 9, pp. 2323-9, 1999 (PubMed).

Vaccari, Moroni, Rocchi et al.: "The human gene coding for HCN2, a pacemaker channel of the heart." in: Biochimica et biophysica acta, Vol. 1446, Issue 3, pp. 419-25, 1999 (PubMed).

Grimwood, Gordon, Olsen et al.: "The DNA sequence and biology of human chromosome 19." in: Nature, Vol. 428, Issue 6982, pp. 529-35, 2004 (PubMed).

Hosts (40), (22), (1)
Reactivities (49), (40), (29), (17), (17), (2)
Applications (49), (28), (22), (20), (18), (14), (3), (3), (2), (2), (1)
Conjugates (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (20), (9), (3), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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