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Details for Product No. ABIN350765

Proteinase 3 (PRTN3) (Internal Region) antibody

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Synonyms ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, mPR3, ela2, MGC132250
»Alternatives Internal Region
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350765
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal region of human Pr3 (Leukocyte proteinase 3, AGP7, Myeloblastin, Wegener autoantigen) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for Pr3.
Purity whole serum
Alternative Name Pr3 (Wegener autoantigen)
Background Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to s.
Catalytic activity: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-. Also known as: Leukocyte proteinase 3, AGP7, Myeloblastin, Wegener autoantigen, PR-3, P29, C-ANCA antigen, Neutrophil proteinase 4, MBN, PRTN3, NP-4.
UniProt P24158
Application Notes WB. A dilution of 1: 200 to 1: 1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Labbaye, Musette, Cayre: "Wegener autoantigen and myeloblastin are encoded by a single mRNA." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 20, pp. 9253-6, 1991 (PubMed).

Jenne, Tschopp, Luedemann et al.: "Wegener's autoantigen decoded." in: Nature, Vol. 346, Issue 6284, pp. 520, 1990 (PubMed).

Duke-Cohan, Morimoto, Rocker et al.: "A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26)." in: The Journal of biological chemistry, Vol. 270, Issue 23, pp. 14107-14, 1995 (PubMed).

Fujinaga, Chernaia, Halenbeck et al.: "The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies." in: Journal of molecular biology, Vol. 261, Issue 2, pp. 267-78, 1996 (PubMed).

Grimwood, Gordon, Olsen et al.: "The DNA sequence and biology of human chromosome 19." in: Nature, Vol. 428, Issue 6982, pp. 529-35, 2004 (PubMed).

Alternatives for antigen "Proteinase 3 (PRTN3)", type "Antibodies"
Hosts (61), (45), (3), (1), (1)
Reactivities (91), (17), (16), (1), (1), (1)
Applications (78), (64), (14), (12), (10), (10), (10), (10), (8), (5), (4), (3), (3), (2)
Conjugates (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (6), (3), (2), (2), (2), (1)