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proBDNF (pro Brain-derived neurotrophic factor) antibody
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|7 references available|
|Quantity||100 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide from rat proBDNF (pro BDNF, pro Brain-derived neurotrophic factor) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse and zebrafish and shares 96% identity with human sequence.|
|Description||FUNCTION: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted. Also known as: Brain-derived neurotrophic factor precursor, proBDNF, pro BDNF.|
|Specificity||Appears to be specific for proBDNF.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Ohara, Gahara, Teraoka et al.: "A rat brain-derived neurotrophic factor-encoding gene generates multiple transcripts through alternative use of 5' exons and polyadenylation sites." in: Gene, Vol. 121, Issue 2, pp. 383-6, 1992 (PubMed).
Maisonpierre, Le Beau, Espinosa et al.: "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations." in: Genomics, Vol. 10, Issue 3, pp. 558-68, 1991 (PubMed).
Yancopoulos, Maisonpierre, Ip et al.: "Neurotrophic factors, their receptors, and the signal transduction pathways they activate." in: Cold Spring Harbor symposia on quantitative biology, Vol. 55, pp. 371-9, 1992 (PubMed).
Hallboeoek, Ibuaunez, Persson: "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary." in: Neuron, Vol. 6, Issue 5, pp. 845-58, 1991 (PubMed).
Timmusk, Palm, Metsis et al.: "Multiple promoters direct tissue-specific expression of the rat BDNF gene." in: Neuron, Vol. 10, Issue 3, pp. 475-89, 1993 (PubMed).
Liu, Lu, Zhu et al.: "Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine." in: Brain research, Vol. 1067, Issue 1, pp. 1-12, 2006 (PubMed).
Aid, Kazantseva, Piirsoo et al.: "Mouse and rat BDNF gene structure and expression revisited." in: Journal of neuroscience research, Vol. 85, Issue 3, pp. 525-35, 2007 (PubMed).
|Hosts||Rabbit (2), Sheep (1)|
|Reactivities||Mouse (Murine) (1), Rat (Rattus) (1), Zebrafish (Danio rerio) (1)|
|Applications||Immunohistochemistry (IHC) (3), Western Blotting (WB) (3)|