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Pro BDNF antibody

proBDNF Reactivity: Rat IHC, WB Host: Sheep Polyclonal unconjugated
Catalog No. ABIN350770
  • Target See all Pro BDNF (proBDNF) products
    Pro BDNF (proBDNF) (Pro-Brain-Derived Neurotrophic Factor (proBDNF))
    Reactivity
    • 5
    • 4
    • 2
    Rat
    Host
    • 3
    • 2
    • 1
    Sheep
    Clonality
    • 4
    • 2
    Polyclonal
    Conjugate
    • 5
    • 1
    This Pro BDNF antibody is un-conjugated
    Application
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Specificity
    Specific for proBDNF.
    Cross-Reactivity
    Mouse, Rat
    Cross-Reactivity (Details)
    Other species not yet tested.
    Purification
    IgG
    Immunogen
    A synthetic peptide from rat proBDNF conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and zebrafish and shares 96% identity with human sequence.
    Isotype
    IgG
  • Application Notes
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Target
    Pro BDNF (proBDNF) (Pro-Brain-Derived Neurotrophic Factor (proBDNF))
    Abstract
    proBDNF Products
    Background
    FUNCTION: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted.,BDNF,Brain-derived neurotrophic factor precursor, proBDNF, pro BDNF
    UniProt
    P23363
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