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Pyx (pyx) (AA 400-450) antibody

Details for Product No. ABIN350776
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Antigen
Synonyms CG17142, CT33412, Dmel\\CG17142, Pyx
Epitope
AA 400-450
Reactivity
Fruit Fly (Drosophila melanogaster)
Host
Rabbit
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 2 references available
Quantity 100 µL
Options
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Catalog No. ABIN350776
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Immunogen A synthetic peptide from aa region 400-450 of drosophila PYX conjugated to blue carrier protein was used as the antigen.
Specificity Specific for PYX.
Purification Whole serum
Alternative Name PYX
Background Function: Receptor-activated non-selective cation channel involved in protection or tolerance from high temperature stress. Activated by temperatures above 40 degrees Celsius. More permeable to K(+) than to Na(+). May act in stress protection allow flies to survive in natural environments.
Subunit: Homooligomer, between isoform A and isoform B.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in various peripheral nerves and the central nerves in embryos. In adults, it is expressed in sensory neurons lying beneath the bristles around eyes, neurons innervating the bristles on the back of thorax and neurons in maxillary palps, proboscis and antennae. Expressed in multidendritic neurons, which mediate temperature sensing, as well as non-multidendritic neurons in larval epidermis. Localizes ubiquitously throughout neurites. Also known as: Transient receptor potential channel pyrexia.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Adams, Celniker, Holt et al.: "The genome sequence of Drosophila melanogaster." in: Science (New York, N.Y.), Vol. 287, Issue 5461, pp. 2185-95, 2000 (PubMed).

Lee, Lee, Lee et al.: "Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster." in: Nature genetics, Vol. 37, Issue 3, pp. 305-10, 2005 (PubMed).

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