Pyx (pyx) (Cytoplasmic Loop) antibody

Details for Product No. ABIN350776
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Antigen
Synonyms CG17142, CT33412, Dmel\\CG17142, Pyx
Epitope
Cytoplasmic Loop
Reactivity
Human
Host
Rabbit
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN350776
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from 1t cytoplasmic loop of drosophila PYX (Transient receptor potential channel pyrexia) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for Synapsin-2.
Purification whole serum
Alternative Name PYX (Transient receptor potential channel pyrexia)
Background Function: Receptor-activated non-selective cation channel involved in protection or tolerance from high temperature stress. Activated by temperatures above 40 degrees Celsius. More permeable to K(+) than to Na(+). May act in stress protection allow flies to survive in natural environments.
Subunit: Homooligomer, between isoform A and isoform B.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in various peripheral nerves and the central nerves in embryos. In adults, it is expressed in sensory neurons lying beneath the bristles around eyes, neurons innervating the bristles on the back of thorax and neurons in maxillary palps, proboscis and antennae. Expressed in multidendritic neurons, which mediate temperature sensing, as well as non-multidendritic neurons in larval epidermis. Localizes ubiquitously throughout neurites. Also known as: Transient receptor potential channel pyrexia.
UniProt Q64332
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Adams, Celniker, Holt et al.: "The genome sequence of Drosophila melanogaster." in: Science (New York, N.Y.), Vol. 287, Issue 5461, pp. 2185-95, 2000 (PubMed).

Lee, Lee, Lee et al.: "Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster." in: Nature genetics, Vol. 37, Issue 3, pp. 305-10, 2005 (PubMed).

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