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RAB7, Member RAS Oncogene Family (RAB7) (AA 160-205) antibody

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Synonyms RAB7, Rab7a, rab-7, zgc:64058, PRO2706, Rab7
AA 160-205
(13), (10), (3), (3)
Human, Mouse (Murine)
(30), (15), (15), (1), (1), (1), (1)
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(18), (11), (8), (6), (4), (3)
Pubmed 5 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from aa region 160-205 of human RAB7 conjugated to blue carrier protein has been used as the antigen. The peptide is homologous in mouse and xenopus.
Specificity Specific for RAB7.
Purification Whole serum
Alternative Name RAB7 (RAB7 Antibody Abstract)
Background Function: Involved in late endocytic transport. Contributes to the maturation of phagosomes (acidification).
Subcellular location: Late endosome. Lysosome. Cytoplasmic vesicle, phagosome. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue specificity: Widely expressed, high expression found in skeletal muscle. DISEASE: Defects in RAB7A are the cause of Charcot-Marie-Tooth disease type 2B (CMT2B) also known as hereditary motor and sensory neuropathy II (HMSN2). CMT2B is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2B is clinically characterized by marked distal muscle weakness and a high frequency of foot ulcers, infections and amputations of the toes. CMT2B inheritance is autosomal dominant. Also known as: RAB7A, RAB7.
Research Area Signaling, Organelles
Pathways EGFR Signaling Pathway
Application Notes Use at a dilution of 1:300 to 1: 2000.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Chi, Valencia, Hu et al.: "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." in: Journal of proteome research, Vol. 5, Issue 11, pp. 3135-44, 2006 (PubMed).

Meggouh, Bienfait, Weterman et al.: "Charcot-Marie-Tooth disease due to a de novo mutation of the RAB7 gene." in: Neurology, Vol. 67, Issue 8, pp. 1476-8, 2006 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Verhoeven, De Jonghe, Coen et al.: "Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy." in: American journal of human genetics, Vol. 72, Issue 3, pp. 722-7, 2003 (PubMed).

Vitelli, Chiariello, Lattero et al.: "Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid." in: Biochemical and biophysical research communications, Vol. 229, Issue 3, pp. 887-90, 1997 (PubMed).

Catalog No. ABIN350785
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