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Details for Product No. ABIN350785

RAB7A, Member RAS Oncogene Family (RAB7A) (Internal Region) antibody

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PRO2706, RAB7, Rab7, rab7, Rab7a, pro2706, RAB7A, LOC100231734, ARABIDOPSIS RAB GTPASE HOMOLOG G2, ATRAB7A, ATRABG2, F7D8.20, F7D8_20, RAB GTPase homolog 7A, DDBDRAFT_0190210, DDBDRAFT_0191507, DDB_01 ... show more
»Alternatives Internal Region
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350785
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal part of human Ras-related protein Rab-7a (RAB7A, RAB7) conjugated to an immunogenic carrier protein has been used as the immunogen. The antigen is homologous in mouse and xenopus.
Specificity Appears to be specific for RAB7.
Purity whole serum
Alternative Name Ras-related protein Rab-7a (RAB7A, RAB7)
Background Function: Involved in late endocytic transport. Contributes to the maturation of phagosomes (acidification).
Subcellular location: Late endosome. Lysosome. Cytoplasmic vesicle, phagosome. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue specificity: Widely expressed, high expression found in skeletal muscle. DISEASE: Defects in RAB7A are the cause of Charcot-Marie-Tooth disease type 2B (CMT2B) also known as hereditary motor and sensory neuropathy II (HMSN2). CMT2B is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2B is clinically characterized by marked distal muscle weakness and a high frequency of foot ulcers, infections and amputations of the toes. CMT2B inheritance is autosomal dominant. Also known as: RAB7A, RAB7.
UniProt P51149
Application Notes IHC, WB. Use at a dilution of 1:300 to 1: 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Vitelli, Chiariello, Lattero et al.: "Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid." in: Biochemical and biophysical research communications, Vol. 229, Issue 3, pp. 887-90, 1997 (PubMed).

Verhoeven, De Jonghe, Coen et al.: "Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy." in: American journal of human genetics, Vol. 72, Issue 3, pp. 722-7, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Meggouh, Bienfait, Weterman et al.: "Charcot-Marie-Tooth disease due to a de novo mutation of the RAB7 gene." in: Neurology, Vol. 67, Issue 8, pp. 1476-8, 2006 (PubMed).

Chi, Valencia, Hu et al.: "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." in: Journal of proteome research, Vol. 5, Issue 11, pp. 3135-44, 2006 (PubMed).

Alternatives for antigen "RAB7A, Member RAS Oncogene Family (RAB7A)", type "Antibodies"
Hosts (19)
Reactivities (16), (7), (5), (4), (2), (2), (2), (2), (2)
Applications (18), (5), (5), (2), (2), (1), (1), (1), (1)
Epitopes (2), (2), (1), (1), (1), (1)