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Retina and Anterior Neural Fold Homeobox (RAX) (Internal Region) antibody

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CG10052, DRx, Dmel\\CG10052, Drx, E97, PPH17, W60, bk50, drx, wom, RAX, RAXL, RX1, RX2, Rx-like, cRax1, cRaxL, rx, rx1, Rx2A, Xrax, Xrx1, rax, AV120107, PRK, Pact, lear, dyt16, pact, prkra-a, prkra-b, ... show more
CG10052, DRx, Dmel\\CG10052, Drx, E97, PPH17, W60, bk50, drx, wom, RAX, RAXL, RX1, RX2, Rx-like, cRax1, cRaxL, rx, rx1, Rx2A, Xrax, Xrx1, rax, AV120107, PRK, Pact, lear, dyt16, pact, prkra-a, prkra-b, rbpa, MCOP3, RX, Rx, 7530406A22Rik, E130303K03Rik, ey-1, ey1 show less
Internal Region
(7), (6), (4), (4), (2), (2), (1), (1)
Human, Rat (Rattus), Mouse (Murine)
(28), (7), (6), (2), (1)
(16), (12)
Immunohistochemistry (IHC), Western Blotting (WB)
(26), (14), (6), (4), (2), (1)
Pubmed 4 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal region of human RAX conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for RAX.
Purification Whole serum
Alternative Name RAX (RAX Antibody Abstract)
Background Function: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter. Defects in RAX are the cause of microphthalmia isolated type 3 (MCOP3). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present.
Tissue specificity: Expressed in the developing eye and weakly expressed in the adult retina.
Subcellular location: Nucleus Also known as: Retina and anterior neural fold homeobox protein, Retinal homeobox protein Rx.
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Pathways Regulatory RNA Pathways
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Product cited in: Rohde, Klein, Møller et al.: "Rax : developmental and daily expression patterns in the rat pineal gland and retina." in: Journal of neurochemistry, 2011 (PubMed). Further details: The nitrocellulose membrane was blocked with 2% (w/v) skim milk in phosphate-buffered saline (PBS) and incubated overnight at 4

Background publications Voronina, Kozhemyakina, OKernick et al.: "Mutations in the human RAX homeobox gene in a patient with anophthalmia and sclerocornea." in: Human molecular genetics, Vol. 13, Issue 3, pp. 315-22, 2004 (PubMed).

Kimura, Singh, Wawrousek et al.: "Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression." in: The Journal of biological chemistry, Vol. 275, Issue 2, pp. 1152-60, 2000 (PubMed).

Furukawa, Kozak, Cepko: "rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 7, pp. 3088-93, 1997 (PubMed).

Catalog No. ABIN350791
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