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Details for Product No. ABIN350791

Retina and Anterior Neural Fold Homeobox (RAX) (Internal Region) antibody

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Antigen
Synonyms
AV120107, PRK, Pact, RAX, lear, dyt16, pact, prkra-a, prkra-b, rax, rbpa, Rx, RX, MCOP3, ey1, ey-1, 7530406A22Rik, E130303K03Rik, CG10052, DRx, Dmel\\CG10052, Drx, E97, PPH17, W60, bk50, drx, wom, RAX ... show more
Epitope
»Alternatives Internal Region
Reactivity
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350791
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal region of human RAX conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for RAX.
Purity whole serum
Alternative Name RAX
Background Function: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter. Defects in RAX are the cause of microphthalmia isolated type 3 (MCOP3). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present.
Tissue specificity: Expressed in the developing eye and weakly expressed in the adult retina.
Subcellular location: Nucleus Also known as: Retina and anterior neural fold homeobox protein, Retinal homeobox protein Rx.
UniProt Q9Y2V3
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Product cited in: Rohde, Klein, Møller et al.: "Rax : developmental and daily expression patterns in the rat pineal gland and retina." in: Journal of neurochemistry, 2011 (PubMed). Further details: The nitrocellulose membrane was blocked with 2% (w/v) skim milk in phosphate-buffered saline (PBS) and incubated overnight at 4

Furukawa, Kozak, Cepko: "rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 7, pp. 3088-93, 1997 (PubMed).

Kimura, Singh, Wawrousek et al.: "Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression." in: The Journal of biological chemistry, Vol. 275, Issue 2, pp. 1152-60, 2000 (PubMed).

Voronina, Kozhemyakina, OKernick et al.: "Mutations in the human RAX homeobox gene in a patient with anophthalmia and sclerocornea." in: Human molecular genetics, Vol. 13, Issue 3, pp. 315-22, 2004 (PubMed).

Alternatives for antigen "Retina and Anterior Neural Fold Homeobox (RAX)", type "Antibodies"
Hosts (17), (10)
Reactivities (25), (5), (3), (2), (2), (1), (1)
Applications (27), (13), (6), (4), (3)
Epitopes (9), (5), (4), (2), (2)
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