RND1 antibody (rho Family GTPase 1)

Details for Product anti-RND1 Antibody No. ABIN350794, Supplier: Log in to see
Antigen
  • rho6
  • XRnd1
  • MGC68867
  • arhs
  • rnd1b
  • rno6
  • A830014L09Rik
  • Arhs
  • ARHS
  • RHO6
  • RHOS
  • Rho family GTPase 1
  • rnd1
  • Rnd1
  • RND1
Reactivity
Human
12
2
2
2
2
2
2
2
1
1
1
1
1
Host
Rabbit
7
6
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
11
4
3
3
2
1
1
Options
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Immunogen Synthetic peptides (dimer) from human Rho related GTP binding protein Rho6 (RND1) conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for RND1.
Alternative Name Rho6 (RND1 Antibody Abstract)
Background Function: Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.
Subcellular location: Cell membrane, Lipid-anchor, Cytoplasmic side. Cytoplasm › cytoskeleton.
Tissue specificity: Mostly expressed in brain and liver. Also known as: Rho family GTPase 1, RND1, RHO6.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Oinuma, Katoh, Harada, Negishi: "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25671-7, 2003 (PubMed).

Katoh, Harada, Mori, Negishi: "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers." in: Molecular and cellular biology, Vol. 22, Issue 9, pp. 2952-64, 2002 (PubMed).

Aoki, Katoh, Mori, Negishi: "Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells." in: Biochemical and biophysical research communications, Vol. 278, Issue 3, pp. 604-8, 2000 (PubMed).

Vayssière, Zalcman, Mahé, Mirey, Ligensa, Weidner, Chardin, Camonis: "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family." in: FEBS letters, Vol. 467, Issue 1, pp. 91-6, 2000 (PubMed).

Nobes, Lauritzen, Mattei, Paris, Hall, Chardin: "A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion." in: The Journal of cell biology, Vol. 141, Issue 1, pp. 187-97, 1998 (PubMed).