Ras Homolog Gene Family, Member U (RHOU) (Internal Region) antibody

Details for Product No. ABIN350805
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Synonyms arhu, hg28k, wrch1, wrch-1, cdc42l1, MGC107947, fj646b12.2, ARHU, CDC42L1, DJ646B12.2, WRCH1, fJ646B12.2, hG28K, 2310026M05Rik, AI182090, Arhu, G28K, WRCH-1, mG28K
Internal Region
(8), (4), (2), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(29), (20), (15), (2)
(24), (9)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(16), (10), (10), (6), (2)
Pubmed 5 references available
Quantity 100 μL
Shipping to United States (Change)
Availability Will be delivered in 7 to 8 Business Days
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Catalog No. ABIN350805
454.67 $
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Immunogen A synthetic peptide from the internal region of human Rho related GTP binding protein RhoU (CDC42 like GTPase 1, CDC42L1, Ryu GTPase) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 90% identity with rat and mouse sequence.
Specificity Specific for RhoU.
Purification Whole serum
Alternative Name RhoU
Background Function: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound.
Subcellular location: Cell membrane, Lipid-anchor, Cytoplasmic side. Golgi apparatus membrane, Lipid-anchor. Cell junction › focal adhesion. Cell projection › podosome. Note: Localizes to podosomes in SRC-transformed cells.
Tissue specificity: Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta. Also known as: Rho related GTP binding protein RhoU, RhoU, Ryu GTPase, CDC42-like GTPase 1, Rho GTPase-like protein ARHU, GTP-binding protein-like 1, ARHU, CDC42L1, G28K, WRCH1, Wnt-1 responsive Cdc42 homolog 1.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Ory, Brazier, Blangy: "Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration." in: Biology of the cell / under the auspices of the European Cell Biology Organization, Vol. 99, Issue 12, pp. 701-16, 2007 (PubMed).

Bubb, Bovee, Buckley et al.: "Scan of human genome reveals no new Loci under ancient balancing selection." in: Genetics, Vol. 173, Issue 4, pp. 2165-77, 2006 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Tao, Pennica, Xu et al.: "Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1." in: Genes & development, Vol. 15, Issue 14, pp. 1796-807, 2001 (PubMed).

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