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Scrambled Cathelicidin antibody

Details for Product No. ABIN350824, Supplier: Log in to see
Antigen
Reactivity
Human
Host
Rabbit
Clonality
Polyclonal
Application
Control Antibody (CAb)
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Immunogen A synthetic scrambled peptide form of human Cathelicidin antimicrobial peptide (CAP-18, hCAP-18, antibacterial protein LL-37, CAMP, CRAMP, FALL39) conjugated to an immunogenic carrier protein has been used as the antigen.
Specificity Specific for scrambled form of Cathelicidin antimicrobial peptide (ie the antigen).
Purification Whole serum
Background Cathelicidin antimicrobial protein is an antimicrobial protein found in specific granules of polymorphonuclear leukocytes.
Function: Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
Subcellular location: Secreted.
Tissue specificity: Expressed in bone marrow and testis and neutrophils. Also known as: CAMP, CAP18, FALL39, FALL-39, 18 kDa cationic antimicrobial protein, CAP-18, hCAP-18, LL37, CRAMP, HSD26.
Application Notes Use at a dilution of 1:100 to 1: 2000.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Bals, Lang, Weiner, Vogelmeier, Welsch, Wilson: "Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules." in: Clinical and diagnostic laboratory immunology, Vol. 8, Issue 2, pp. 370-5, 2001 (PubMed).

Larrick, Lee, Ma, Li, Francke, Wright, Balint: "Structural, functional analysis and localization of the human CAP18 gene." in: FEBS letters, Vol. 398, Issue 1, pp. 74-80, 1997 (PubMed).

Gudmundsson, Agerberth, Odeberg, Bergman, Olsson, Salcedo: "The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes." in: European journal of biochemistry / FEBS, Vol. 238, Issue 2, pp. 325-32, 1996 (PubMed).

Agerberth, Gunne, Odeberg, Kogner, Boman, Gudmundsson: "FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 1, pp. 195-9, 1995 (PubMed).

Cowland, Johnsen, Borregaard: "hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules." in: FEBS letters, Vol. 368, Issue 1, pp. 173-6, 1995 (PubMed).

Larrick, Hirata, Balint, Lee, Zhong, Wright: "Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein." in: Infection and immunity, Vol. 63, Issue 4, pp. 1291-7, 1995 (PubMed).