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Details for Product No. ABIN350826

Sequestosome 1 (SQSTM1) antibody

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Synonyms p60, p62, A170, OSIL, PDB3, ZIP3, p62B, Osi, STAP, OSF-6, sb:cb621, zgc:85784, ZIP, SQSTM1, sqstm1, MGC79491
»Alternatives Sheep
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 10 references available
Catalog no. ABIN350826
Quantity 150 µL
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide as a part of sequestosome-1 (ubiquitin-binding protein p62, p60, EBIAP) conjugated to immunogenic carrier protein has been used as the immunogen.
Specificity Appears to be specific for sequestosome-1.
Purity whole serum
Alternative Name Sequestosome-1 (SQSTM1, ubiquitin-binding protein p62, p60)
Background Function: Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
Subcellular location: Cytoplasm. Late endosome. Nucleus. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.
Tissue specificity: Ubiquitously expressed. Also known as: Sequestosome 1, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, ubiquitin-binding protein p62, EBI3-associated protein of 60 kDa, p60, EBIAP, SQSTM1, A170, OSIL, PDB3, ZIP3, p62B.
UniProt Q13501
Application Notes IHC (both on frozen and paraffin embedded tissues), WB. Use at a dilution of 1 : 200 to 1 : 2000. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Devergne, Hummel, Koeppen et al.: "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes." in: Journal of virology, Vol. 70, Issue 2, pp. 1143-53, 1996 (PubMed).

Joung, Strominger, Shin: "Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 12, pp. 5991-5, 1996 (PubMed).

Vadlamudi, Joung, Strominger et al.: "p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins." in: The Journal of biological chemistry, Vol. 271, Issue 34, pp. 20235-7, 1996 (PubMed).

Stumptner, Heid, Fuchsbichler et al.: "Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent." in: The American journal of pathology, Vol. 154, Issue 6, pp. 1701-10, 1999 (PubMed).

Hocking, Lucas, Daroszewska et al.: "Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease." in: Human molecular genetics, Vol. 11, Issue 22, pp. 2735-9, 2002 (PubMed).

Ciani, Layfield, Cavey et al.: "Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37409-12, 2003 (PubMed).

Hocking, Lucas, Daroszewska et al.: "Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 19, Issue 7, pp. 1122-7, 2004 (PubMed).

Good, Busfield, Fletcher et al.: "Identification of SQSTM1 mutations in familial Paget's disease in Australian pedigrees." in: Bone, Vol. 35, Issue 1, pp. 277-82, 2004 (PubMed).

Nousiainen, Silljé, Sauer et al.: "Phosphoproteome analysis of the human mitotic spindle." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 14, pp. 5391-6, 2006 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Alternatives for antigen "Sequestosome 1 (SQSTM1)", type "Antibodies"
Hosts (65), (12), (4), (4)
Reactivities (81), (28), (27), (14), (12), (12), (1), (1)
Applications (69), (29), (25), (21), (18), (12), (10), (8), (6), (3), (2), (2), (1), (1)
Conjugates (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (16), (14), (7), (7), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)