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Superoxide Dismutase 3, Extracellular (SOD3) (AA 10-50) antibody

Details for Product No. ABIN350843
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Antigen
Synonyms SOD3, LOC780439, fb05f10, si:dkey-117m1.6, sod3, wu:fb05f10, EC-SOD, AI314465, ECSODPT, ECSOD, SODA.4
Epitope
AA 10-50
(6), (5), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(70), (29), (19), (12), (12), (12)
Host
Rabbit
(48), (33), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(71), (52), (34), (27), (14), (10), (8), (6), (3), (3), (1)
Pubmed 5 references available
Quantity 100 µL
Options
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Catalog No. ABIN350843
454.67 $
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Immunogen A synthetic peptide from aa region 10-50 of human SOD3 conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for SOD3.
Purification Whole serum
Alternative Name SOD3
Background Function: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Catalytic activity: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
Tissue specificity: Expressed in blood vessels, heart, lungs, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.
Subcellular location: Secreted › extracellular space. Note: 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium. Also known as: Superoxide dismutase 3, SODE, SOD E.
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Adachi, Ohta, Hayashi et al.: "The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro." in: Free radical biology & medicine, Vol. 13, Issue 3, pp. 205-10, 1992 (PubMed).

Hjalmarsson, Marklund, Engström et al.: "Isolation and sequence of complementary DNA encoding human extracellular superoxide dismutase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 18, pp. 6340-4, 1987 (PubMed).

Folz, Crapo: "Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene." in: Genomics, Vol. 22, Issue 1, pp. 162-71, 1994 (PubMed).

Adachi, Morihara, Yamazaki et al.: "An arginine-213 to glycine mutation in human extracellular-superoxide dismutase reduces susceptibility to trypsin-like proteinases." in: Journal of biochemistry, Vol. 120, Issue 1, pp. 184-8, 1997 (PubMed).

Nozik-Grayck, Suliman, Piantadosi: "Extracellular superoxide dismutase." in: The international journal of biochemistry & cell biology, Vol. 37, Issue 12, pp. 2466-71, 2005 (PubMed).

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