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Details for Product No. ABIN350849

Sodium Channel Protein Type 1 Subunitalpha (SCN1A, Nav1.1) (C-Term) antibody

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Rat (Rattus), Human
Clonality Polyclonal
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350849
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the c-terminal of Sodium channel protein type 1 subunit alpha (SCN1A, Nav1.1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologus in rat and human.
Specificity Appears to be specific for SCN1A.
Purity whole serum
Background Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Sodium channel protein type 1 subunit alpha, Sodium channel protein type I subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.1, Sodium channel protein, brain I subunit alpha, SCN1A, NAC1, SCN1.
UniProt P35498
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Lu, Han, Rado et al.: "Differential expression of two sodium channel subtypes in human brain." in: FEBS letters, Vol. 303, Issue 1, pp. 53-8, 1992 (PubMed).

Malo, Blanchard, Andresen et al.: "Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24." in: Cytogenetics and cell genetics, Vol. 67, Issue 3, pp. 178-86, 1994 (PubMed).

Escayg, MacDonald, Meisler et al.: "Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2." in: Nature genetics, Vol. 24, Issue 4, pp. 343-5, 2000 (PubMed).

Hillier, Graves, Fulton et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).

Vahedi, Depienne, Le Fort et al.: "Elicited repetitive daily blindness: a new phenotype associated with hemiplegic migraine and SCN1A mutations." in: Neurology, Vol. 72, Issue 13, pp. 1178-83, 2009 (PubMed).