Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) (C-Term) antibody

Antigen: Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A)

Synonyms: FEB3, NAC1, SCN1, SMEI, HBSCI, GEFSP2, Nav1.1, SCN9A, SCN1A

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350849

Additional Information

Alternative name: Sodium channel protein type 1 subunitalpha (SCN1A, Nav1.1) (c-terminal)

Swiss-Prot: P35498

Immunogen: A synthetic peptide from the c-terminal of Sodium channel protein type 1 subunit alpha (SCN1A, Nav1.1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologus in rat and human.

Format: Lyophilized

Description: FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Also known as: Sodium channel protein type 1 subunit alpha, Sodium channel protein type I subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.1, Sodium channel protein, brain I subunit alpha, SCN1A, NAC1, SCN1.

Specificity: Appears to be specific for SCN1A.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Lu, Han, Rado et al.: "Differential expression of two sodium channel subtypes in human brain." in: FEBS letters, Vol. 303, Issue 1, pp. 53-8, 1992 (PubMed).

Malo, Blanchard, Andresen et al.: "Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24." in: Cytogenetics and cell genetics, Vol. 67, Issue 3, pp. 178-86, 1994 (PubMed).

Escayg, MacDonald, Meisler et al.: "Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2." in: Nature genetics, Vol. 24, Issue 4, pp. 343-5, 2000 (PubMed).

Hillier, Graves, Fulton et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).

Vahedi, Depienne, Le Fort et al.: "Elicited repetitive daily blindness: a new phenotype associated with hemiplegic migraine and SCN1A mutations." in: Neurology, Vol. 72, Issue 13, pp. 1178-83, 2009 (PubMed).