Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) (C-Term) antibody

Details for Product No. ABIN350849
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Antigen
Synonyms SCN9A, SCN1A, B230332M13, Nav1.1, EIEE6, FEB3, FEB3A, FHM3, GEFSP2, HBSCI, NAC1, SCN1, SMEI
Epitope
C-Term
(21), (19), (2), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(37), (26), (19), (12), (12), (2), (1)
Host
Rabbit
(23), (23)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(32), (24), (20), (20), (10), (10), (3), (2), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 100 μL
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Catalog No. ABIN350849
454.67 $
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Immunogen A synthetic peptide from the c-terminal of Sodium channel protein type 1 subunit alpha (SCN1A, Nav1.1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologus in rat and human.
Specificity Specific for SCN1A.
Purification Whole serum
Alternative Name SCN1A
Background Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Sodium channel protein type 1 subunit alpha, Sodium channel protein type I subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.1, Sodium channel protein, brain I subunit alpha, SCN1A, NAC1, SCN1.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Lu, Han, Rado et al.: "Differential expression of two sodium channel subtypes in human brain." in: FEBS letters, Vol. 303, Issue 1, pp. 53-8, 1992 (PubMed).

Malo, Blanchard, Andresen et al.: "Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24." in: Cytogenetics and cell genetics, Vol. 67, Issue 3, pp. 178-86, 1994 (PubMed).

Escayg, MacDonald, Meisler et al.: "Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2." in: Nature genetics, Vol. 24, Issue 4, pp. 343-5, 2000 (PubMed).

Hillier, Graves, Fulton et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).

Vahedi, Depienne, Le Fort et al.: "Elicited repetitive daily blindness: a new phenotype associated with hemiplegic migraine and SCN1A mutations." in: Neurology, Vol. 72, Issue 13, pp. 1178-83, 2009 (PubMed).

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