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Sodium channel protein type 1 subunitalpha (SCN1A, Nav1.1) (C-Term) antibody
Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide from the c-terminal of Sodium channel protein type 1 subunit alpha (SCN1A, Nav1.1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologus in rat and human.|
|Description||FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Also known as: Sodium channel protein type 1 subunit alpha, Sodium channel protein type I subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.1, Sodium channel protein, brain I subunit alpha, SCN1A, NAC1, SCN1.|
|Specificity||Appears to be specific for SCN1A.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Lu, Han, Rado et al.: "Differential expression of two sodium channel subtypes in human brain." in: FEBS letters, Vol. 303, Issue 1, pp. 53-8, 1992 (PubMed).
Malo, Blanchard, Andresen et al.: "Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24." in: Cytogenetics and cell genetics, Vol. 67, Issue 3, pp. 178-86, 1994 (PubMed).
Escayg, MacDonald, Meisler et al.: "Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2." in: Nature genetics, Vol. 24, Issue 4, pp. 343-5, 2000 (PubMed).
Hillier, Graves, Fulton et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).
Vahedi, Depienne, Le Fort et al.: "Elicited repetitive daily blindness: a new phenotype associated with hemiplegic migraine and SCN1A mutations." in: Neurology, Vol. 72, Issue 13, pp. 1178-83, 2009 (PubMed).