Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) (N-Term) antibody

Details for Product No. ABIN350850
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Antigen
Synonyms Nav1.8, PN3, SNS, hPN3, Na(V)1.8
Epitope
N-Term
(20), (4), (1)
Reactivity
Human
(33), (17), (14), (12), (12), (12), (2)
Host
Rabbit
(23), (15), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(27), (23), (21), (19), (10), (3), (3), (2), (2), (1)
Pubmed 2 references available
Quantity 100 µL
Options
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Catalog No. ABIN350850
454.67 $
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Immunogen A synthetic peptide from the n-terminal region of human Nav1.8 conjugated to blue carrier protein was used as the antigen.
Specificity Specific for Nav1.8.
Purification Whole serum
Alternative Name Nav1.8
Background Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms.
Tissue specificity: Expressed in the dorsal root ganglia and sciatic nerve.
Subcellular location: Cell membrane, Multi-pass membrane protein. Note: It can be translocated to the extracellular membrane through association with S100A10. Also known as: Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8, Peripheral nerve sodium channel 3, hPN3, SCN10A, PN3.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Rabert, Koch, Ilnicka et al.: "A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A." in: Pain, Vol. 78, Issue 2, pp. 107-14, 1999 (PubMed).

Muzny, Scherer, Kaul et al.: "The DNA sequence, annotation and analysis of human chromosome 3. ..." in: Nature, Vol. 440, Issue 7088, pp. 1194-8, 2006 (PubMed).

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