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Sodium channel protein type 10 subunitalpha (SCN10A, Nav1.8) (N-Term) antibody
Immunohistochemistry (IHC), Western Blotting (WB)
|2 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide from the n-terminal region of human Sodium channel protein type 10 subunit alpha (SCN10A, Nav1.8) conjugated to an immunogenic carrier protein was used as the immunogen.|
|Description||FUNCTION: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms. Tissue specificity: Expressed in the dorsal root ganglia and sciatic nerve. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note: It can be translocated to the extracellular membrane through association with S100A10. Also known as: Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8, Peripheral nerve sodium channel 3, hPN3, SCN10A, PN3.|
|Specificity||Appears to be specific for SCN10A.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Rabert, Koch, Ilnicka et al.: "A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A." in: Pain, Vol. 78, Issue 2, pp. 107-14, 1999 (PubMed).
Muzny, Scherer, Kaul et al.: "The DNA sequence, annotation and analysis of human chromosome 3." in: Nature, Vol. 440, Issue 7088, pp. 1194-8, 2006 (PubMed).