Sodium channel protein type 10 subunitalpha (SCN10A, Nav1.8) (N-Term) antibody

Antigen: Sodium channel protein type 10 subunitalpha (SCN10A, Nav1.8)

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350850

Additional Information

UniProt: Q9Y5Y9

Immunogen: A synthetic peptide from the n-terminal region of human Sodium channel protein type 10 subunit alpha (SCN10A, Nav1.8) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms. Tissue specificity: Expressed in the dorsal root ganglia and sciatic nerve. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note: It can be translocated to the extracellular membrane through association with S100A10. Also known as: Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8, Peripheral nerve sodium channel 3, hPN3, SCN10A, PN3.

Specificity: Appears to be specific for SCN10A.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Rabert, Koch, Ilnicka et al.: "A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A." in: Pain, Vol. 78, Issue 2, pp. 107-14, 1999 (PubMed).

Muzny, Scherer, Kaul et al.: "The DNA sequence, annotation and analysis of human chromosome 3." in: Nature, Vol. 440, Issue 7088, pp. 1194-8, 2006 (PubMed).