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Details for Product No. ABIN350851

Sodium Channel Protein Type 11 Subunitalpha (SCN11A, Nav1.9) (Internal Region) antibody

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Antigen
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350851
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal region of human Sodium channel protein type 11 subunit alpha (SCN11A, Nav1.9) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for SCN11A.
Purity whole serum
Background Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
Tissue specificity: Expressed in the dorsal root ganglia and trigeminal ganglia,olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Sodium channel protein type XI subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.9, Sensory neuron sodium channel 2, Peripheral nerve sodium channel 5, hNaN, SCN11A, PN5, SCN12A, SNS2.
UniProt Q9UI33
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Dib-Hajj, Tyrrell, Cummins et al.: "Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons." in: FEBS letters, Vol. 462, Issue 1-2, pp. 117-20, 2000 (PubMed).

Jeong, Goto, Hashida et al.: "Identification of a novel human voltage-gated sodium channel alpha subunit gene, SCN12A." in: Biochemical and biophysical research communications, Vol. 267, Issue 1, pp. 262-70, 2000 (PubMed).

Blum, Kafitz, Konnerth: "Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9." in: Nature, Vol. 419, Issue 6908, pp. 687-93, 2002 (PubMed).

Raymond, Castle, Garrett-Engele et al.: "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia." in: The Journal of biological chemistry, Vol. 279, Issue 44, pp. 46234-41, 2004 (PubMed).

Muzny, Scherer, Kaul et al.: "The DNA sequence, annotation and analysis of human chromosome 3." in: Nature, Vol. 440, Issue 7088, pp. 1194-8, 2006 (PubMed).

Alternatives for antigen "Sodium Channel Protein Type 11 Subunitalpha (SCN11A, Nav1.9)", type "Antibodies"
Hosts (1)
Reactivities (1)
Applications (1)
Epitopes (1)
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