Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) (Internal Region) antibody

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  • SCN11A
  • NSS2
  • NaN
  • NaT
  • SNS2
  • NAV1.9
  • SCN12A
  • SNS-2
  • sodium channel, voltage-gated, type XI, alpha subunit
  • sodium channel, voltage-gated, type XI, alpha
  • SCN11A
  • Scn11a
Internal Region
Immunohistochemistry (IHC), Western Blotting (WB)
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Immunogen A synthetic peptide from the internal region of human Sodium channel protein type 11 subunit alpha (SCN11A, Nav1.9) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for SCN11A.
Purification Whole serum
Alternative Name SCN11A (SCN11A Antibody Abstract)
Background Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
Tissue specificity: Expressed in the dorsal root ganglia and trigeminal ganglia,olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Sodium channel protein type XI subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.9, Sensory neuron sodium channel 2, Peripheral nerve sodium channel 5, hNaN, SCN11A, PN5, SCN12A, SNS2.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Muzny, Scherer, Kaul, Wang, Yu, Sudbrak, Buhay, Chen, Cree, Ding, Dugan-Rocha, Gill, Gunaratne, Harris, Hawes, Hernandez, Hodgson, Hume, Jackson, Khan, Kovar-Smith, Lewis, Lozado, Metzker et al.: "The DNA sequence, annotation and analysis of human chromosome 3. ..." in: Nature, Vol. 440, Issue 7088, pp. 1194-8, 2006 (PubMed).

Raymond, Castle, Garrett-Engele, Armour, Kan, Tsinoremas, Johnson: "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia." in: The Journal of biological chemistry, Vol. 279, Issue 44, pp. 46234-41, 2004 (PubMed).

Blum, Kafitz, Konnerth: "Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9." in: Nature, Vol. 419, Issue 6908, pp. 687-93, 2002 (PubMed).

Dib-Hajj, Tyrrell, Cummins, Black, Wood, Waxman: "Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons." in: FEBS letters, Vol. 462, Issue 1-2, pp. 117-20, 2000 (PubMed).

Jeong, Goto, Hashida, Suzuki, Ogata, Masuda, Hirai, Isahara, Uchiyama, Kanazawa: "Identification of a novel human voltage-gated sodium channel alpha subunit gene, SCN12A." in: Biochemical and biophysical research communications, Vol. 267, Issue 1, pp. 262-70, 2000 (PubMed).

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