Sodium channel protein type 11 subunitalpha (SCN11A, Nav1.9) (Internal Region) antibody

Antigen: Sodium channel protein type 11 subunitalpha (SCN11A, Nav1.9)

Binding Site: Internal Region

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350851

Additional Information

UniProt: Q9UI33

Immunogen: A synthetic peptide from the internal region of human Sodium channel protein type 11 subunit alpha (SCN11A, Nav1.9) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. Tissue specificity: Expressed in the dorsal root ganglia and trigeminal ganglia,olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Also known as: Sodium channel protein type XI subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.9, Sensory neuron sodium channel 2, Peripheral nerve sodium channel 5, hNaN, SCN11A, PN5, SCN12A, SNS2.

Specificity: Appears to be specific for SCN11A.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Dib-Hajj, Tyrrell, Cummins et al.: "Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons." in: FEBS letters, Vol. 462, Issue 1-2, pp. 117-20, 2000 (PubMed).

Jeong, Goto, Hashida et al.: "Identification of a novel human voltage-gated sodium channel alpha subunit gene, SCN12A." in: Biochemical and biophysical research communications, Vol. 267, Issue 1, pp. 262-70, 2000 (PubMed).

Blum, Kafitz, Konnerth: "Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9." in: Nature, Vol. 419, Issue 6908, pp. 687-93, 2002 (PubMed).

Raymond, Castle, Garrett-Engele et al.: "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia." in: The Journal of biological chemistry, Vol. 279, Issue 44, pp. 46234-41, 2004 (PubMed).

Muzny, Scherer, Kaul et al.: "The DNA sequence, annotation and analysis of human chromosome 3." in: Nature, Vol. 440, Issue 7088, pp. 1194-8, 2006 (PubMed).