Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A) (internal) antibody

Antigen: Sodium Channel, Voltage-Gated, Type XI, alpha Subunit (SCN11A)

Synonyms: NaN, NaT, NSS2, SNS2, SNS-2, NAV1.9, SCN12A, SCN11A

Epitope: internal

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN350852

Additional Information

Alternative name: Sodium channel protein type 11 subunitalpha (SCN11A, Nav1.9) (internal region)

Swiss-Prot: Q9R053

Immunogen: A synthetic peptide from the internal region of mouse Sodium channel protein type 11 subunit alpha (SCN11A, Nav1.9) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. Tissue specificity: Expressed in the dorsal root ganglia and trigeminal ganglia,olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Also known as: Sodium channel protein type XI subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.9, Sensory neuron sodium channel 2, Peripheral nerve sodium channel 5, hNaN, SCN11A, PN5, SCN12A, SNS2.

Specificity: Appears to be specific for SCN11A.

Application Details

Application Notes: IHC. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Dib-Hajj, Tyrrell, Black et al.: "NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 15, pp. 8963-8, 1998 (PubMed).

Tate, Benn, Hick et al.: "Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons." in: Nature neuroscience, Vol. 1, Issue 8, pp. 653-5, 1999 (PubMed).

Benn, Costigan, Tate et al.: "Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 16, pp. 6077-85, 2001 (PubMed).

Delmas, Coste: "Na+ channel Nav1.9: in search of a gating mechanism." in: Trends in neurosciences, Vol. 26, Issue 2, pp. 55-7, 2003 (PubMed).