Sodium Channel, Voltage-Gated, Type III, alpha (SCN3A) (C-Term) antibody

Antigen: Sodium Channel, Voltage-Gated, Type III, alpha (SCN3A)

Synonyms: NAC3, Nav1.3, KIAA1356, Gm1000, SCIII, Scn2a

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350853

Additional Information

Alternative name: Sodium channel protein type 3 subunitalpha (SCN3A, Nav1.3) (c-terminal)

Swiss-Prot: Q9NY46

Immunogen: A synthetic peptide from the c-terminal of human Sodium channel protein type 3 subunit alpha (SCN3A, Nav1.3) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Also known as: Sodium channel protein type III subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.3, Sodium channel protein, brain III subunit alpha, Voltage-gated sodium channel subtype III, SCN3A, NAC3.

Specificity: Appears to be specific for SCN3A.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Malo, Srivastava, Andresen et al.: "Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 8, pp. 2975-9, 1994 (PubMed).

Kasai, Fukushima, Ueki et al.: "Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus." in: Gene, Vol. 264, Issue 1, pp. 113-22, 2001 (PubMed).

Weiss, Escayg, Kearney et al.: "Sodium channels SCN1A, SCN2A and SCN3A in familial autism." in: Molecular psychiatry, Vol. 8, Issue 2, pp. 186-94, 2003 (PubMed).

Hillier, Graves, Fulton et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).