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Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) (C-Term) antibody

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Synonyms SCN3A, nav1.3, Gm1000, Nav1.3, SCIII, Scn2a, NAC3
(5), (3), (2), (2), (2), (1)
(33), (15), (14)
(28), (6)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(16), (11), (9), (8), (6), (1), (1)
Pubmed 4 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the c-terminal of human Sodium channel protein type 3 subunit alpha (SCN3A, Nav1.3) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for SCN3A.
Purification Whole serum
Alternative Name SCN3A (SCN3A Antibody Abstract)
Background Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Sodium channel protein type III subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.3, Sodium channel protein, brain III subunit alpha, Voltage-gated sodium channel subtype III, SCN3A, NAC3.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Hillier, Graves, Fulton et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).

Weiss, Escayg, Kearney et al.: "Sodium channels SCN1A, SCN2A and SCN3A in familial autism." in: Molecular psychiatry, Vol. 8, Issue 2, pp. 186-94, 2003 (PubMed).

Kasai, Fukushima, Ueki et al.: "Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus." in: Gene, Vol. 264, Issue 1, pp. 113-22, 2001 (PubMed).

Malo, Srivastava, Andresen et al.: "Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 8, pp. 2975-9, 1994 (PubMed).

Catalog No. ABIN350853
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