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Details for Product No. ABIN350854

Sodium Channel Protein Type 4 Subunitalpha (SCN4A, Nav1.4) (N-Term) antibody

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Mouse (Murine), Rat (Rattus), Human
Clonality Polyclonal
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350854
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the n-terminal of mouse Sodium channel protein type 4 subunit alpha (SCN4A, Nav1.4) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in human and rat.
Specificity Appears to be specific for SCN4A.
Purity whole serum
Background Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Sodium channel protein type IV subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.4, Sodium channel protein skeletal muscle subunit alpha, SkM1, SCN4A.
UniProt Q9ER60
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Wang, Rojas, Zhou et al.: "Sequence and genomic structure of the human adult skeletal muscle sodium channel alpha subunit gene on 17q." in: Biochemical and biophysical research communications, Vol. 182, Issue 2, pp. 794-801, 1992 (PubMed).

McClatchey, Van den Bergh, Pericak-Vance et al.: "Temperature-sensitive mutations in the III-IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita." in: Cell, Vol. 68, Issue 4, pp. 769-74, 1992 (PubMed).

George, Komisarof, Kallen et al.: "Primary structure of the adult human skeletal muscle voltage-dependent sodium channel." in: Annals of neurology, Vol. 31, Issue 2, pp. 131-7, 1992 (PubMed).

Ptuacek, George, Barchi et al.: "Mutations in an S4 segment of the adult skeletal muscle sodium channel cause paramyotonia congenita." in: Neuron, Vol. 8, Issue 5, pp. 891-7, 1992 (PubMed).

Luan, Chen, Liu et al.: "Tubular aggregates in paralysis periodica paramyotonica with T704M mutation of SCN4A." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 29, Issue 5, pp. 579-84, 2009 (PubMed).