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Sodium Channel, Voltage-Gated, Type IV, alpha Subunit (SCN4A) (AA 30-80) antibody

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Antigen
  • Nav1.4
  • SkM1
  • mH2
  • HOKPP2
  • HYKPP
  • HYPP
  • NAC1A
  • Na(V)1.4
  • NCHVS
  • microI
Epitope
AA 30-80
4
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
13
6
6
Host
Rabbit
13
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
12
7
2
1
1
Supplier
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Immunogen A synthetic peptide from aa region 30-80 of mouse Nav1.4 (SCN4A) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in human and rat.
Specificity Specific for SCN4A.
Purification Whole serum
Alternative Name Nav1.4 (SCN4A Antibody Abstract)
Background Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Sodium channel protein type IV subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.4, Sodium channel protein skeletal muscle subunit alpha, SkM1, SCN4A.
Pathways
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Luan, Chen, Liu et al.: "Tubular aggregates in paralysis periodica paramyotonica with T704M mutation of SCN4A." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 29, Issue 5, pp. 579-84, 2009 (PubMed).

Ptuacek, George, Barchi et al.: "Mutations in an S4 segment of the adult skeletal muscle sodium channel cause paramyotonia congenita." in: Neuron, Vol. 8, Issue 5, pp. 891-7, 1992 (PubMed).

George, Komisarof, Kallen et al.: "Primary structure of the adult human skeletal muscle voltage-dependent sodium channel." in: Annals of neurology, Vol. 31, Issue 2, pp. 131-7, 1992 (PubMed).

McClatchey, Van den Bergh, Pericak-Vance et al.: "Temperature-sensitive mutations in the III-IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita." in: Cell, Vol. 68, Issue 4, pp. 769-74, 1992 (PubMed).

Wang, Rojas, Zhou et al.: "Sequence and genomic structure of the human adult skeletal muscle sodium channel alpha subunit gene on 17q." in: Biochemical and biophysical research communications, Vol. 182, Issue 2, pp. 794-801, 1992 (PubMed).