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Sodium channel protein type 4 subunitalpha (SCN4A, Nav1.4) (N-Term) antibody
Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide from the n-terminal of mouse Sodium channel protein type 4 subunit alpha (SCN4A, Nav1.4) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in human and rat.|
|Description||FUNCTION: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Also known as: Sodium channel protein type IV subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.4, Sodium channel protein skeletal muscle subunit alpha, SkM1, SCN4A.|
|Specificity||Appears to be specific for SCN4A.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Wang, Rojas, Zhou et al.: "Sequence and genomic structure of the human adult skeletal muscle sodium channel alpha subunit gene on 17q." in: Biochemical and biophysical research communications, Vol. 182, Issue 2, pp. 794-801, 1992 (PubMed).
McClatchey, Van den Bergh, Pericak-Vance et al.: "Temperature-sensitive mutations in the III-IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita." in: Cell, Vol. 68, Issue 4, pp. 769-74, 1992 (PubMed).
George, Komisarof, Kallen et al.: "Primary structure of the adult human skeletal muscle voltage-dependent sodium channel." in: Annals of neurology, Vol. 31, Issue 2, pp. 131-7, 1992 (PubMed).
Ptuacek, George, Barchi et al.: "Mutations in an S4 segment of the adult skeletal muscle sodium channel cause paramyotonia congenita." in: Neuron, Vol. 8, Issue 5, pp. 891-7, 1992 (PubMed).
Luan, Chen, Liu et al.: "Tubular aggregates in paralysis periodica paramyotonica with T704M mutation of SCN4A." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 29, Issue 5, pp. 579-84, 2009 (PubMed).