Sodium Channel, Voltage-Gated, Type VII, alpha (SCN7A) (internal) antibody

Antigen: Sodium Channel, Voltage-Gated, Type VII, alpha (SCN7A)

Epitope: internal

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350856

Additional Information

Alternative name: Sodium channel protein type 7 subunitalpha (SCN7A, SCN6A, Nax) (internal region)

Swiss-Prot: Q01118

Immunogen: A synthetic peptide from the internal region of human Sodium channel protein type 7 subunit alpha (SCN7A, SCN6A, Nax) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. Tissue specificity: Heart and uterus. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Also known as: Sodium channel protein type VII subunit alpha, Putative voltage-gated sodium channel subunit alpha Nax, Sodium channel protein cardiac and skeletal muscle subunit alpha, SCN7A, SCN6A, Nax.

Specificity: Appears to be specific for SCN7A (also known as SCN6A).

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: George, Knittle, Tamkun: "Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 11, pp. 4893-7, 1992 (PubMed).