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Details for Product No. ABIN350859

Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (N-Term), (pan), (Internal Region) antibody

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Antigen
Synonyms Nav1.7, PN1, mKIAA4197, Scn2a, ETHA, FEB3B, GEFSP7, NE-NA, NENA, SFNP, SCN9A, SCN1A, DKFZp459G084
Epitope
»Alternatives N-Term, pan, Internal Region
Reactivity
»Alternatives Rat (Rattus), Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350859
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the extracellular domain of rat amiloride sensitive cation channel 3 (ACCN3, ASIC3, SLNAC1, TNAC1) conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for ASIC3.
Purity whole serum
Alternative Name SCN9A
Background Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na+ channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.
Tissue specificity: Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system while isoform 2 is expressed preferentially in the dorsal root ganglion.
Subcellular location: Cell membrane, Multi-pass membrane protein. Note: In neurite terminals Also known as: Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.7, Neuroendocrine sodium channel, Peripheral sodium channel 1, SCN9A, NENA, PN1.
UniProt Q6X1Y6
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Sangameswaran, Fish, Koch et al.: "A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia." in: The Journal of biological chemistry, Vol. 272, Issue 23, pp. 14805-9, 1997 (PubMed).

Yang, Wang, Li et al.: "Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia." in: Journal of medical genetics, Vol. 41, Issue 3, pp. 171-4, 2004 (PubMed).

Raymond, Castle, Garrett-Engele et al.: "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia." in: The Journal of biological chemistry, Vol. 279, Issue 44, pp. 46234-41, 2004 (PubMed).

Fertleman, Baker, Parker et al.: "SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes." in: Neuron, Vol. 52, Issue 5, pp. 767-74, 2006 (PubMed).

Cox, Reimann, Nicholas et al.: "An SCN9A channelopathy causes congenital inability to experience pain." in: Nature, Vol. 444, Issue 7121, pp. 894-8, 2006 (PubMed).

Alternatives for antigen "Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A)", type "Antibodies"
Hosts (27), (9), (2)
Reactivities (36), (25), (22), (13), (13)
Applications (18), (17), (13), (10), (6), (3), (3), (2), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (3), (2), (2), (1)
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