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SCN9A antibody (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit) (AA 1000-1050)

Details for Product anti-SCN9A Antibody No. ABIN350859, Supplier: Log in to see
Antigen
  • DKFZp459G084
  • ETHA
  • FEB3B
  • GEFSP7
  • mKIAA4197
  • Nav1.7
  • NE-NA
  • NENA
  • PN1
  • Scn2a
  • SCN9A
  • SFNP
Epitope
AA 1000-1050
43
36
8
3
2
2
1
1
1
1
1
1
1
Reactivity
Human
75
33
32
18
2
2
2
2
Host
Rabbit
43
24
11
Clonality
Polyclonal
Conjugate
This SCN9A antibody is un-conjugated
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
52
36
36
35
24
15
7
2
2
1
Supplier
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Immunogen A synthetic peptide from aa region 1000-1050 of human Nav1.7 conjugated to blue carrier protein was used as the antigen.
Specificity Specific for SCN9A.
Purification Whole serum
Alternative Name Nav1.7 (SCN9A Antibody Abstract)
Background Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na+ channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.
Tissue specificity: Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system while isoform 2 is expressed preferentially in the dorsal root ganglion.
Subcellular location: Cell membrane, Multi-pass membrane protein. Note: In neurite terminals Also known as: Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.7, Neuroendocrine sodium channel, Peripheral sodium channel 1, SCN9A, NENA, PN1.
Research Area Signaling, Metabolism
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Cox, Reimann, Nicholas, Thornton, Roberts, Springell, Karbani, Jafri, Mannan, Raashid, Al-Gazali, Hamamy, Valente, Gorman, Williams, McHale, Wood, Gribble, Woods: "An SCN9A channelopathy causes congenital inability to experience pain." in: Nature, Vol. 444, Issue 7121, pp. 894-8, 2006

Fertleman, Baker, Parker, Moffatt, Elmslie, Abrahamsen, Ostman, Klugbauer, Wood, Gardiner, Rees: "SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes." in: Neuron, Vol. 52, Issue 5, pp. 767-74, 2006

Raymond, Castle, Garrett-Engele, Armour, Kan, Tsinoremas, Johnson: "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia." in: The Journal of biological chemistry, Vol. 279, Issue 44, pp. 46234-41, 2004

Yang, Wang, Li, Xu, Li, Ma, Fan, Bu, Liu, Fan, Wu, Jin, Ding, Zhu, Shen: "Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia." in: Journal of medical genetics, Vol. 41, Issue 3, pp. 171-4, 2004

Sangameswaran, Fish, Koch, Rabert, Delgado, Ilnicka, Jakeman, Novakovic, Wong, Sze, Tzoumaka, Stewart, Herman, Chan, Eglen, Hunter: "A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia." in: The Journal of biological chemistry, Vol. 272, Issue 23, pp. 14805-9, 1997