Sortilin-Related VPS10 Domain Containing Receptor 3 (SORCS3) (C-Term) antibody

Antigen: Sortilin-Related VPS10 Domain Containing Receptor 3 (SORCS3)

Synonyms: SORCS, RP11-107L7.1, AW045579, 6330404A12Rik

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350860

Additional Information

Alternative name: SORCS3 (VPS10 domain containing receptor SorCS3)

UniProt: Q9UPU3

Immunogen: A synthetic peptide from the c-terminal region of human SORCS3 (VPS10 domain containing receptor SorCS3) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 95% identity with mouse sequence.

Format: Lyophilized

Description: This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins. Subcellular location: Membrane; Single-pass type I membrane protein.Tissue specificity: Highly expressed in brain. Also known as: SORCS 3, SORCS, Sortilin related VPS10 domain containing receptor 3, VPS10 domain containing receptor SorCS3, VPS10 domain receptor protein SORCS 3.

Specificity: Appears to be specific for SORCS3.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Kikuno, Nagase, Ishikawa et al.: "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 6, Issue 3, pp. 197-205, 1999 (PubMed).

Hampe, Rezgaoui, Hermans-Borgmeyer et al.: "The genes for the human VPS10 domain-containing receptors are large and contain many small exons." in: Human genetics, Vol. 108, Issue 6, pp. 529-36, 2001 (PubMed).

Deloukas, Earthrowl, Grafham et al.: "The DNA sequence and comparative analysis of human chromosome 10." in: Nature, Vol. 429, Issue 6990, pp. 375-81, 2004 (PubMed).