SorLA (SORL,Sortilin Related Receptor, Sorting Protein Related Receptor Containing) (C-Term) antibody

Antigen: SorLA (SORL,Sortilin Related Receptor, Sorting Protein Related Receptor Containing)

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350862

Additional Information

Alternative name: SorLA (SORL,Sortilin related receptor, Sorting protein related receptor containing) (c-terminal)

Swiss-Prot: O88307

Immunogen: A synthetic peptide from c-terminal of mouse SorLA (Sortilin related receptor, Sorting protein related receptor containing) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Abundant in brain, where it is mainly expressed in adult cerebellum, hippocampal ca regions, dentate gyrus, and to a much lesser extent in the cerebral cortex. Detectable in kidney, skeletal muscle, lung and spleen, but not in the liver. DEVELOPMENTAL STAGE: Expressed as early as embryonic day 6.5 (E6.5) and peaks at E11, the main location is in the CNS during development. At early stages, it is abundant in a subpopulation of neurons in the cerebral cortex, in the hippocampus, and granular and Purkinje cell layers in the cerebellum, whereas in the adult, expression in cerebellar granular cells and in the cerebral cortex is low. Expression occurs also in a variety of glands and organs during organogenesis. Also known as: Sortilin-related receptor, Sortilin related receptor, Sorting protein related receptor containing LDLR class A repeats, mSorLA, SorLA-1, Low density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand binding repeats, LR11, Gp250, SORL.

Specificity: Appears to be specific for SORLA.

Application Details

Application Notes: IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Hermans-Borgmeyer, Hampe, Schinke et al.: "Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex." in: Mechanisms of development, Vol. 70, Issue 1-2, pp. 65-76, 1998 (PubMed).

Kanaki, Bujo, Hirayama et al.: "Developmental regulation of LR11 expression in murine brain." in: DNA and cell biology, Vol. 17, Issue 8, pp. 647-57, 1998 (PubMed).