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Details for Product No. ABIN350873

Sorting Nexin 1 (Nexin-1, SNX1) (C-Term) antibody

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Antigen
Epitope
C-Term
Reactivity
Mouse (Murine), Rat (Rattus), Human
Host
Rabbit
Clonality Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350873
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the c-terminal of mouse Sorting nexin 1 (Nexin-1, SNX1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and human.
Specificity Appears to be specific for Sorting nexin 1.
Purity whole serum
Background Function: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with PtdIns(3,4,5)P3 and, with weaker affinity, with PtdIns(3,5)P2.
Subcellular location: Endosome membrane, Peripheral membrane protein, Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane, Peripheral membrane protein, Cytoplasmic side. Also known as: Nexin 1, SNX1, Nexin-1.
UniProt Q9WV80
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Nakamura, Sun-Wada, Yamamoto et al.: "Association of mouse sorting nexin 1 with early endosomes." in: Journal of biochemistry, Vol. 130, Issue 6, pp. 765-71, 2001 (PubMed).

Zhong, Watson, Lazar et al.: "Determinants of the endosomal localization of sorting nexin 1." in: Molecular biology of the cell, Vol. 16, Issue 4, pp. 2049-57, 2005 (PubMed).

Zody, Garber, Sharpe et al.: "Analysis of the DNA sequence and duplication history of human chromosome 15." in: Nature, Vol. 440, Issue 7084, pp. 671-5, 2006 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

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