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STAM 1, 2 (Internal Region) antibody

Details for Product No. ABIN350878
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Antigen
Epitope
Internal Region
(1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(2), (2), (2)
Host
Rabbit
(2)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(2), (2)
Pubmed 5 references available
Quantity 500 µg
Options
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Catalog No. ABIN350878
454.67 $
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Immunogen A synthetic peptide from the internal part of human STAM 1, 2 (STAM-1, STAM-2) conjugated to an immunogenic carrier protein was used as the immunogen. The peptide is homologous in many species including rat, mouse, zebra fish and xenopus.
Isotype IgG
Specificity Specific for STAM1 & 2.
Background STAM1:
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in endocytic trafficking as well as in T-cell development.
Subunit: Heterodimer. Composed of STAM1 and HGS/HRS. Also interacts directly with STAMBP/AMSH.
Tissue specificity: Ubiquitously expressed. STAM2:
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Probably acts via its association with ubiquitinated cargo proteins on the early endosome participates in their sorting for trafficking to the lysosome. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a in T-cell development.
Subunit: Heterodimer or heterotrimer. At least composed of STAM2 and HGS/Hrs. EPS15 can be part of the complex. Interacts directly with STAMBP/AMSH, JAK2 and JAK3. Also interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY. Interacts directly with CBX5 via the PxVxL motif. Interacts with VPS37C.
Tissue specificity: Ubiquitously expressed. Also known as: STAM1, STAM-1, STAM2, STAM-2, Signal transducing adapter molecule 1, Signal transducing adapter molecule 2, HBP, Hrs-binding protein.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Takeshita, Arita, Asao et al.: "Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM." in: Biochemical and biophysical research communications, Vol. 225, Issue 3, pp. 1035-9, 1996 (PubMed).

Asao, Sasaki, Arita et al.: "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth." in: The Journal of biological chemistry, Vol. 272, Issue 52, pp. 32785-91, 1998 (PubMed).

Steen, Kuster, Fernandez et al.: "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway." in: The Journal of biological chemistry, Vol. 277, Issue 2, pp. 1031-9, 2002 (PubMed).

Hillier, Graves, Fulton et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

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