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Details for Product No. ABIN350880

Stromal Interaction Molecule 1 (STIM1) (Extracellular Domain) antibody

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Synonyms D11S4896E, GOK, TAM, SIM, stim1, MGC76045, STIM1, si:dkey-24p1.5, MGC154748, si:ch211-112l17.2, Stim1
»Alternatives Extracellular Domain
»Alternatives Mouse (Murine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350880
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the extracellular domain of human Stromal interaction molecule 1 (STIM1) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for DOC2B.
Purity whole serum
Alternative Name Stromal interaction molecule 1 (STIM1, GOK)
Background Function: Plays a role in mediating Ca2+ influx following depletion of intracellular Ca2+ stores. Acts as Ca2+ sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca2+ depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca2+ release-activated Ca2+ (CRAC) channel subunit, TMEM142A/ORAI1.
Subcellular location: Cell membrane, Single-pass type I membrane protein. Endoplasmic reticulum membrane, Single-pass type I membrane protein. Note: Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium.
Tissue specificity: Ubiquitously expressed in various human primary cells and tumor cell lines. Also known as: STIM1, GOK.
UniProt Q14184
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Parker, Begley, Smith et al.: "Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5." in: Genomics, Vol. 37, Issue 2, pp. 253-6, 1997 (PubMed).

Sabbioni, Barbanti-Brodano, Croce et al.: "GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development." in: Cancer research, Vol. 57, Issue 20, pp. 4493-7, 1997 (PubMed).

Manji, Parker, Williams et al.: "STIM1: a novel phosphoprotein located at the cell surface." in: Biochimica et biophysica acta, Vol. 1481, Issue 1, pp. 147-55, 2000 (PubMed).

Williams, Manji, Parker et al.: "Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins." in: The Biochemical journal, Vol. 357, Issue Pt 3, pp. 673-85, 2001 (PubMed).

Chen, Jiang, Sun et al.: "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." in: Journal of proteome research, Vol. 8, Issue 2, pp. 651-61, 2009 (PubMed).

Alternatives for antigen "Stromal Interaction Molecule 1 (STIM1)", type "Antibodies"
Hosts (59), (19), (2)
Reactivities (71), (51), (50), (29), (27), (20), (17), (2)
Applications (65), (25), (24), (15), (15), (11), (11), (10), (9), (2), (1), (1), (1)
Conjugates (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (24), (8), (3), (3), (3), (2), (2), (2), (2), (1), (1)